stress responsive systems can have direct effects on gene transcription it may be important to consider stress-related gene transcription for such phenotypes (Arloth et al., 2015) and basal expression may not be as informative. Consistent with this notion, glucocorticoid-related gene expression outperforms baseline gene expression when predicting depression [though notably such data should be interpreted as preliminary given the relatively small current sample sizes; (Menke et al., 2012)].
