With respect to the cannabis literature, cue-elicited craving for cannabis represents a potentially powerful, and untapped, endophenotype for research on genetic factors related to cannabis abuse. To date, there is only one published study of cue-elicited craving for cannabis. In this report, scripts describing an individual experiencing cannabis craving were used to manipulate craving [25]. The results of this study demonstrated the reliability and validity of a marijuana craving measure (the Marijuana Craving Questionnaire) and demonstrated that this measure was sensitive to script condition (no urge, low urge and high urge), demonstrating that imagery scripts can be used to elicit craving for cannabis.