CaMKII contributes to drug-induced hyperlocomotion and locomotor sensitization. In rats, repeated intra-VTA treatment with the glutamate receptor agonist t-ACPD enhances cocaine-induced hyperlocomotion, and this effect is attenuated by intra-VTA injection of KN93.253 In rats, repeated cocaine administration induces locomotor sensitization, which is inhibited by intra-VTA injection of KN93243 and partially attenuated by intra-NAc injection of KN93.254 CaMKII knockout mice develop cocaine-induced locomotor sensitization, but the magnitude of the sensitization is significantly less than in wild-type mice.243
