The control subjects for GWAS2 were psychiatrically healthy individuals who had been randomly selected from a Munich community sample, and who had been screened using the Composite International Diagnostic Interview. This control sample was distinct from the control sample used in the follow-up study. In view of the limited financial resources available for genotyping, this sample was chosen since GWAS data were already available and the controls were from the same region as the majority of our patients. The mean age at interview was 51.9, SD=13.2 for this control sample and mean=50.5, SD=12.1 for the overall control sample. All of the GWAS phenotypes and genotypes are stored in a comprehensive database at the Institute for Medical Biometry, Informatics, and Epidemiology in Bonn (IMBIE). The study was approved by the respective local ethics committees and was carried out in accordance with the Declaration of Helsinki. All participants provided written informed consent.
