We examined the degree to which known height SNPs were associated with tooth eruption, and similarly whether SNPs associated with tooth eruption explained variance in height. Our analyses suggest there exists a subset of known height-associated variants, including those in the HMGA2, IGF2BP3, C6orf173 and RAD51L1 loci that are also associated with tooth eruption. This may be due to these variants exerting a generalized pleiotropic effect on many aspects of growth. For example, SNPs in HMGA2 have been previously associated with other growth-related phenotypes, including head circumference (36), intracranial volume (37) and birth weight (39) as well as height (12). Likewise, SNPs at the C6orf173 locus have been associated with age at menarche (40). Despite robust associations of a few, the majority of height-related SNPs were not strongly related to tooth eruption. A weighted allelic score of height-associated variants was not strongly related to tooth eruption and there seemed to be little consistency in the direction of allelic effects for 180 height-associated SNPs across height and tooth eruption phenotypes. Likewise, the majority of genome-wide significant tooth eruption SNPs did not
