Chunk #56 — Results — FGFR inhibitor, PD173074, models loss of nFGFR1 and cortical maldevelopment in hESC cerebral organoids

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Cerebral organoids reveal early cortical maldevelopment in schizophrenia-computational anatomy and genomics, role of FGFR1.

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in rosettes and in the cortical zoneControlPD173074Rosette ROIsBrdUBrdU47.7 ± 3.4 (77%)136.2 ± 22.7 (98%) P = 0.006BrdU + Pan-NeuBrdU + Pan-Neu18.3 ± 1.7 (74%)9.2 ± 2.6 (93%) P = 0.008Cortex ROIsBrdUBrdU14.2 ± 2.1 (23%)2.5 ± 0.9 (2%) P = 0.0007BrdU + Pan-NeuBrdU + Pan-Neu6.5 ± 1.2 (26%)0.7 ± 0.3 (7%) P = 0.002Cells were counted in identical seven ROIs in sections of control and PD173074-treated organoids. Numbers represent mean + SEM; % of cells in rosettes and cortical ROI are shown. Pairwise comparisons were done using t-test with unequal variances