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Chunk #7 — METHODS — Genome-wide association study of DSM-defined nicotine dependence (DSM-NicDep)

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Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.
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We performed follow-up analyses described below (genetic correlations, genomic structural equation modeling, and polygenic scores) only in the European ancestry data, because the African and East Asian ancestry subsets were under-powered.