nearly all cases, these involved duplicated stretches <1 kbp inserted within 5 kbp of the alternate copy, suggesting a common mechanism of SV formation (Extended Data Fig. 10). The remaining inversions comprised ‘Inv and Del’ events (14%), ‘MultiDel’ events exhibiting inverted spacers (7%), and more highly complex sites (5%; Fig. 3d, middle left panel). The appreciable inversion complexity uncovered here is most likely due to a mutational process forming complex SVs, potentially involving DNA replication errors3, rather than due to recurrent rearrangement, as our analyses failed to detect corresponding intermediate events in 1000 Genomes Project samples.
