Almost all of these historical candidate gene studies evaluated the role of common variation (one part of a spectrum of variants involved in schizophrenia). Our evaluation includes: (a) meta-analysis of candidate gene studies, (b) PGC schizophrenia mega-analysis results,11 (c) expert evaluations from researchers on specific candidate genes, and (d) survey ratings from schizophrenia genomics investigators. The latter two approaches are not “scientific” in a strict sense, but rather provide a general guide to the “significance” and “impact” that the earlier findings currently have in the field.
