S.M.H., B.J.H., E.F., P.R., and K.J.B. contributed to the experimental design. S.M.H., B.J.H., E.F., and P.R. completed all cell culture experiments. E.F. cloned gRNAs. S.M.H., B.J.H., E.F., P.R., R.A., N.B., and H.M. performed qPCR and data analysis. I.O. completed western blot analysis. H.P. and S.A. provided critical assistance. S.M.H., B.J.H., and K.J.B. wrote the manuscript.
