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Chunk #4 — Materials and methods — Samples

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Expanding the range of ZNF804A variants conferring risk of psychosis.
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In the initial analysis of rs1344706 association with schizophrenia, genome-wide typed samples from seven European locations were included. After quality control, case/control samples from England (93/88), Finland/excluding Kuusamo (59/147), Finland/Kuusamo (123/50), Iceland (589/11 492), Italy (84/89), the Netherlands (693/3689) and Scotland (658/661) were included. With the exception of the samples from the Netherlands, these samples derived from the genome-wide data described in our primary GWA report.3 Additional samples from Bonn and Munich that were part of the earlier data set were not used here as they had been included in the initial ZNF804A study.4 Bipolar samples from Iceland (N= 404 after quality control) were also incorporated into the psychosis analysis.