then undertaken a simulation study to focus on two distinct, but timely, scenarios with the aim of addressing specific, as yet unanswered, methodological questions in each. First, when deep re-sequencing data are available to discover rare variants, do methods based on accumulations of minor alleles within the same functional unit offer greater power to detect association with complex traits than traditional analysis of SNPs on GWA chips? Second, when only GWA chip data are available, what is the most powerful strategy for identifying rare variant associations with complex traits?
