This is clearly not the case. Patients seem to need to be at least adolescents to express a psychosis related to WM disorder. Younger patients who present one of the many metabolic WM diseases (Krabbe's, Pelizaeus-Merzbacher, Alexander's, and Cockaynes's diseases, ALD, MLD), are generally not reported to manifest psychotic symptoms.59-60 Interestingly, in elderly patients, psychosis with clinical features similar to those of schizophrenia is rare, eg, in Binswanger's disease.
