All subjects were genotyped for an additional five SNPs (rs1551808 (#1), rs7758009 (#2), rs7760028 (#3), rs1074287 (#4), and rs3778146 (#7)) (Table 1, Figure 1). The SNPs were selected from the 100 kb 5′ flanking region, and intron 1 based on LD information from HapMap (CEU blocks 1 and 4) and frequency in CEU (MAF> 0.1). As is shown in Table 2, the five subjects with the “118G”/”118G” pattern (subgroup 1) carry two copies of the three variant alleles (#1-3) of the SNPs from the 5′ region (C-G-C, block 1), two copies of the reference A allele of the 5′ SNP rs1074287 (#4), and two copies for the reference allele of the three SNPs from intron 1 (C-T-T, #6-8). The majority of the heterozygotes for the 118G allele (“REF”/“118G”, subgroup 2) also carry at least one variant allele of the SNPs #1-3 (TC-AG-TC), and none of them carries the variant allele of SNP rs1074287 (#4) or the three IVS1 SNPs (#6-8). The subjects in subgroup “IVS1”/”118G” (subgroup 4) all carry at least one variant allele of SNPs #1-4 (TC-AG-TC-AG). Although the
