Obesity can lead to organ and vascular complications.15 Non-alcoholic fatty liver disease (NAFLD), which are considered the hepatic manifestation of metabolic syndrome, range from benign steatosis to severe non-alcoholic steatohepatitis (NASH), potentially further damaging organs.16 Sustained elevation of neutral lipid accumulation (mostly triglycerides in hepatocyte lipid droplets) initiates early pathological stages. Different fatty acid sources contribute to fatty liver development, including dietary lipid intake, de novo lipogenesis and adipose tissue lipolysis.4 In NAFLD, 60% of fatty acids accumulated in steatotic liver are adipose-derived.17
