Genome-wide two-point parametric LOD score analyses for maximum number of cigarettes per day were performed with FASTLINK [9-11] using gene frequency and genotype-specific phenotypic mean estimates provided by analyses in PAP 4.0 [12] and S.A.G.E. 4.0 [6], which assumed the existence of a major gene. Parametric analyses were performed on unadjusted values and on residuals from a linear regression of maximum number of cigarettes per day on sex and age.
