Chunk #1 — Background — The ideas underlying the data simulation

Source

Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype.

Embedded

yes

Text

One of the most important emerging questions confronting the genetics of common disease concerns gene × gene interaction and its effect on finding and identifying disease-related loci. This problem constitutes a central theme in the design of the simulation.