Chunk #238 — IX. Classes of genes that are identified in multiple GWA samples for multiple phenotypes: focus on “druggable” targets

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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“Druggable” genes that are most strongly supported by the current analyses: Cumulative nominal p values, based on the strongest clusters on nominally positive SNPs in each of these individual genes in studies of a variety of different phenotypes, provide support for individual genes that is as striking as 10− 3 – < 10− 5 for several of these “druggable” genes.