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Chunk #44 — Discussion

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Cortical phase-amplitude coupling is key to the occurrence and treatment of freezing of gait.
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cortical PAC (analogues to lower baseline occupation), contribute to enlarged disposable computational capacity (analogues to higher available bandwidth) that can be used to deal with dynamic cognitive burdens and therefore reduces freezing probability. Notably, since the STN is also actively involved in cognitive processings,55 investigating whether STN-DBS eases freezing also through modulating cognitive circuit (i.e. the dynamic fluctuation in our model) is warranted in the future.