Using our GWAS results and those of other GWASs, we estimated the genetic correlation of lifetime cannabis use with 25 traits of interest, including substance use, personality, and mental health phenotypes. Fourteen traits were significantly genetically correlated with lifetime cannabis use after correction for multiple testing (Figure 4 and Supplementary Table S6). Positive genetic correlations were found with substance use phenotypes, including smoking and alcohol use and dependence, as well as with mental health phenotypes, including ADHD and schizophrenia. Furthermore, positive genetic correlations were found with risk-taking behaviour, openness to experience, and educational attainment, as well as a negative correlation with conscientiousness.
