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Chunk #16 — Materials and Methods — Simulation study

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Generalizing polygenic risk scores from Europeans to Hispanics/Latinos.
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proportions of African ancestries in HCHS/SOL’s Dominican and Puerto-Rican background groups respectively (see Figure 2 in Conomos et al. (2016)). We simulated quantitative traits under a few potential genetic architectures, assuming one or two causal SNPs, which are either shared or different between the two ancestral populations, in the region. Each simulation setting was repeated 500 times. Details about simulating admixed populations genomic association regions and architectures, are provided in the Supplementary Material.