Linden et al. reported imaging results from three subjects with 49,XXXXY: the first was a 21-year-old male with an IQ estimated at 39, little speech, and a history of a seizure disorder, who was found to have mild hydrocephaly and diffuse atrophy of the cerebrum and cerebellum on CT performed at the age of 12. The second male had an IQ of 58 and was found on CT to have mildly enlarged ventricles. The third was a 15-year-old male with an IQ of approximately 40 whose head size was at the 25th percentile, but whose CT was otherwise read as normal [Linden et al., 1995].
