In accordance with the neuropsychological deficits observed, brain abnormalities have been identified in a large network of interconnected areas communicating with each other in feedforward and feedback loops to serve visuospatial cognition. Cortical regions throughout the entire cerebrum are involved, as well as the cerebellum and the thalamus (reviewed by Fitzpatrick et al., 2008, 2012). Morphometry studies have shown volume deficits among alcoholics, compared with controls, within the parietal lobes (Fein et al., 2002; Gazdzinski et al., 2005b; Chanraud et al., 2007), and cortical shrinkage in the parietal lobes has been associated with poor performance in spatial processing (Fein et al., 2009). Although parietal cortical volume (measured with conventional MRI) was not a predictor of visuospatial ability in alcoholics, cerebellar hemispheric white matter was such a predictor (Sullivan, 2003). Rosenbloom et al. (2009) examined associations between regional white matter microstructural integrity (measured with DTI) and visuoconstruction accuracy (as measured by the Rey-Osterrieth Complex Figure Test) in alcoholics and healthy controls. For both groups, the investigators found an association between poorer copy accuracy and increased radial diffusivity in the occipital forceps
