These eLORETA source-localization results are consistent with those of neurophysiological studies suggesting that reduced alpha oscillations in temporal, limbic and parieto-occipital regions, as well as increased slow activity sources in AD are associated with the global cognitive level [65], [66] or the presence of APOE-4 allele [33]. They are also in line with findings from PET and SPECT investigations demonstrating pronounced hypometabolism or reduced blood flow in posterior brain regions in AD, especially in the parietal cortex [67], [68]. Together, these data support the notion of temporal and parieto-occipital cortical deficits, and resting-state DMN dysfunction as important neurobiological features of AD, and confirm a link between APOE-4 and cortical function phenotype.
