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Chunk #6 — Methods — Participants and phenotypes

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On the association of common and rare genetic variation influencing body mass index: a combined SNP and CNV analysis.
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Complete data on height, weight, AD, ND, genotypes and CNVs were available for 1850 EA and 498 AA participants. Descriptive statistics for study variables are presented by sex and self-reported ancestry in Table 1. There was a significant race by sex interaction with BMI (t-test = 6.84, p = 1.01×10−11) indicating that females and AAs tended to have greater BMI. Males were more likely to be AD (χ2 = 286.02, p = 3.65×10−64) and ND (χ2 = 9.36, p = 0.002). The age by AD interaction was also significant (t-test = −3.11, p = 0.002) indicating that older subjects were less likely to be AD.Table 1 Descriptive statistics by sex and self-reported ancestry VariableMenWomen Mean EA (SD) n = 780 Mean AA (SD) n = 231 Mean EA (SD) n = 1070 Mean AA (SD) n = 267 Age 40.4 (9.7)41.1 (8.3)39.3 (9.0)39.3 (6.9) BMI 27.5 (4.6)28.4 (5.1)26.5 (6.5)31.5 (7.3) n (%) n (%) n (%) n (%) Obese 184 (23.6%)72 (31.2%)246 (23.0%)130 (48.7%) AD 501 (64.2%)171 (74.0%)300 (28.0%)120 (44.9%) ND 406 (52.1%)125 (54.1%)466 (43.6%)151 (56.6%)Note: EA = European-American, AA