Fh1 is also associated with two candidate phenotypes: (1) T-cell proliferation (GN ID 10237; q=2.6 × 10−5), linked previously to mitochondrial function20; and (2) dopamine metabolism after treatment with the mitochondrial toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, GN ID 15151; q=0.005). Both traits are linked to Fh1 along with the control of mitochondrial components of a UPRmt pathway (Fig. 3g). No extant human genotype data are yet available for FH—the homolog of Fh1.
