We obtained a similar estimate of SNP heritability using 1000 Genomes imputed data (0.33, SE 0.03, population risk 0.01). For a population risk of 0.004, 4,65 SNP heritability was 0.26 (SE 0.02) using HapMap3 and 0.27 (SE 0.02) using 1000 Genomes imputation. Partitioning of the SNP-heritability by minor allele frequency is consistent with 80% of the signal reflecting causal variants with MAF > 0.1 (Supplemental Table 5).
