Stage 2 validation was conducted for our novel lead SNP, rs1659258, using data from studies not part of the present meta-analysis in the GIANT consortium data in sex-specific meta-analyses for BMI and waist circumference (personal communication, Heid I et al). P-values for SNPs discovered in the present effort in association with adiposity phenotypes reported by the GIANT consortium were queried. We concluded significant results when a direction-consistent p-value was at least p<0.05.
