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Chunk #4 — 2. What constitutes a valid animal model for ASDs?

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Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links.
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Face validity refers to the model’s resemblance to the clinical features of the disorder, both in terms of behavioral symptoms and physiological biomarkers; this definition of face validity can be separated into ethological validity and biomarker validity (Belzung and Lemoine, 2011). Currently, ASD is diagnosed based solely on behavioral assessments, limiting discussion of face validity to the behavioral realm.