As measured by the BAES after the priming drink there was no significant interaction of medication by OPRM1 genotype on stimulation (F(1,79)=0.271, p=0.60) or sedation (F(1,79)=.008, p=0.93) nor was there a main effect of medication on stimulation (F(1,81)=1.08, p=.30) or sedation (F(1,81)=1.12, p=.29). There was a trend (F(1,81)=3.81, p=0.054) for the asn40 allele subjects to have more alcohol stimulation (BAES peak score 12.9 +/− 11.3 for asn40 and 8.3 +/− 9.8 for asp40) but no significant difference on sedation (F(1,81)=0.542, p=.46). Peak blood alcohol level as a covariate had no material effect on these analyzes.
