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Chunk #47 — Discussion

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Testing for measured gene-environment interaction: problems with the use of cross-product terms and a regression model reparameterization solution.
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it will not accurately represent the shape of the interaction in the data. If the researcher did not plot the actual data points and instead relied on a significant p-value associated with the cross-product term as evidence of interaction, this inaccuracy would go unnoticed. Biased estimates and increased Type I and Type II error rates would result.