In summary, we reported that chronic pretreatment with Wy-14643 or fenofibrate in adult mice attenuated neuroinflammation induced by intracerebral injection of LPS. Since fibrates have been prescribed as drugs for many years, more studies are needed to investigate their effects on CNS diseases such as meningitis, stroke, Alzheimer’s disease, cerebrovascular dementia, and epilepsy in which neuroinflammation plays a significant role.
