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Chunk #38 — 5. Reasons for non-replication

Source
Replication in genome-wide association studies.
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yes

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For the last three explanations, it is useful to clarify if the explanation was offered a posteriori after observing the inconsistent results in different studies. Post hoc explanations for subgroup differences, interactions, and effect modification may be overfit to the observed data and may require further prospective replication in further datasets before they can be relied upon.