fit the model to the schizophrenia summary statistics [18] and took the resulting coefficients, replacing negative coefficients with 0. We then scaled these coefficients as needed to give the desired heritability at the desired level of polygenicity. For each simulation, we used stratified LD score regression to estimate total heritability, the heritability of the CNS cell-type group, and the proportion of heritability in the CNS cell-type group.
