Third, our study supports the importance of tempo regulation as a key contextual element in neuronal development and gene-gene interactions. Previous studies have revealed a defined temporal sequence in generating different neuronal subtypes and glia cells during embryonic cortical neurogenesis (Okano and Temple, 2009). Neuronal maturation is also temporally controlled during both early development and adult neurogenesis. We show that this temporal control is essential for the proper neuronal development and dictates DISC1 function in vivo.
