The effect of clonidine on water intake during the daily 2-h free-choice between alcohol and water is presented in Fig. 2. No commonly used data transformations were effective in achieving homogeneity of variance and normal distribution of the water data. Since non-parametric 2-way ANOVA with repeated measures tests are not available, 5 separate non-parametric 1-way ANOVA analyses were conducted, i.e., one each for the Pre-Drug Day, Drug Days 1 and 2, and Post-Drug Days 1 and 2. Kruskal-Wallis 1-way ANOVA on ranks indicated that water intake was not significantly different among the treatment groups on any day.
