phenotypes that would not lead them to be classified among the majority of cases of MD.Table 4Mendelian Conditions in which Major Depression Has Been Listed as a PhenotypeMIMNameClinical FeaturesPrevalenceInheritanceGene#168605Perry sydromeThe earliest and most prominent symptom may be MD not responsive to antidepressant drugs or electroconvulsive therapy. Sleep disturbances, exhaustion, and marked weight loss are features.Eight families in the worldDominantDCTN1#314250Dystonia 3, torsion, X-linked; DYT3The odds ratio for overall MD was increased OR = 2.85, 95% CI = 0.56–5.14) in patients with DYT3 compared to the control group.5.24 in 100,000 on Panay Island, PhilippinesX-linkedTAF1#128100Dystonia 1, torsion, autosomal dominant; DYT1Carriers of DYT1 are over four times more likely than noncarriers to exhibit recurrent MD. Relative risk of 3.62In France, an estimated disease frequency of 0.13 in 100,000DominantDYT1#222300Wolfram syndrome 1; WFS1Additional clinical features include diverse psychiatric disordersHeterozygous carriers of the Wolfram syndrome, estimated to represent approximately 1% of the United States population, are predisposed to MD.RecessiveWFS1The column headed MIM provides the reference number in Mendelian Inheritance in Man (http://www.omim.org).
