experiments are likely to be especially valuable: among the 56 variants that are in strong linkage disequilibrium with a typical GWAS signal, ~15 show strong disequilibrium across our four continental groupings (Table S15). Compared to earlier catalogs, our current resource increases the number of variants in linkage disequilibrium with each GWAS signal by 25% compared to the Pilot phase of the project and by greater than 2-fold compared to the HapMap resource.