Alcohol CTA and CPP have also been examined in the WSP and WSR selected lines, as well as a pair of lines selected for a few generations for High (HAW) vs Low (LAW) Alcohol Withdrawal from the F2 intercross of C57BL/6J and DBA/2J mice (Chester et al. 1998;Risinger et al. 1994). WSP and HAW mice developed stronger CPP than WSR and LAW, respectively. While WSP mice were slightly less sensitive than WSR mice in the CTA test, HAW and LAW lines did not differ. Collectively, these data from mice suggest that enhanced sensitivity to the rewarding effects of alcohol is correlated with a genetic tendency to experience severe withdrawal, and that a tendency toward reduced sensitivity to an aversive effect of alcohol may also be associated.
