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Chunk #93 — Methods/Design — Primary analysis 2: analysis of the impact of 5-HTTLPR variation across all ages — Arm B: stressful life events (including childhood maltreatment)

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Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression.
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This arm of the analyses will include a series of nested analyses. The first will be similar to Arm B of the first primary analyses, except that there is no restriction on the ages of the subjects. Additional analyses will further reduce the restrictions on the included data (e.g. timing need not be known) as we attempt to determine what are the broadest general conditions under which an effect can be detected. As we loosen the restrictions, the sample size will increase allowing the possibility of detecting weaker associations in a broader setting.