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Chunk #17 — Fronto-limbic circuit — Treatments targeting fronto-limbic dysfunctions in OCD

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Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder.
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networks affected by the stimulation [70–71] (Table 3). Indeed, a recent analysis examining tractography correlates of OCD symptom improvement following DBS targeted at different stimulation sites, including the ALIC, indicated that successful reduction of symptoms was associated with connectivity of all stimulation sites to a common fiber bundle [70]. Thus, an important step for future research is to identify the optimal white matter networks associated with different cortical neurocircuit dysfunctions.