Examination of the 651 SNPs in the CNTNAP2 gene (Arking et al. 2008, Bakkaloglu et al. 2008) in our discovery dataset revealed only eight genotyped SNPs that were nominally significant (p-values=0.002-0.04). The results did not significantly improve in male only families (data not shown). The tagging SNP, rs270102, reported by Alarcon et al. (Bakkaloglu et al. 2008), was not significant in either the overall or male only family dataset. SNP rs7794745 showing linkage in Arking et al. (Arking et al. 2008) study was not genotyped in our dataset. Association of imputed genotypes for this SNP was not significant (p=0.62). None of tested markers met gene-wide (CNTNAP2) significance after correction (data not shown).
