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Chunk #17 — RESULTS — Transcriptome analysis of organoids derived from ASD individuals

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FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders.
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were both significantly upregulated and overlapping with genes in the SFARI autism database (Figure 2C). The tan module was characterized by an upregulation at TD31 of transcripts for several potassium channels and for key components of GABAergic neurons, including the GABA synthetic enzyme GAD1 and three GABA receptor subunits, most of which were in the tan module’s 100 hub genes (Table S7).