Piriform (primary olfactory cortical) responses were examined in a Genotype(2) × Condition(2) linear mixed-effects model using NApO, with condition being a repeated measure. As with the smaller sample (Kareken et al., 2010), alcohol infusion did not induce significant changes in either the left or right piriform BOLD response to NApO in this larger group. This suggests that clamped alcohol did not fundamentally change the observed BOLD contrast. There was also no main effect of Genotype in left or right piriform cortex, suggesting no genotype differences in the basic cortical olfactory sensory response.
