avoid troublesome risk probabilities >1 (33). In practice, we have found that the log model is inaccurate if Kλs>0.01 (Supplementary Material, Fig. S1) and therefore agree with Wray and Goddard (33) that this model should not be used for common diseases. A plausible maximum AUC for rare diseases therefore likely lies between 0.96 and 0.98, and common diseases around 0.93, as predicted by the logit and probit models. If future genetic studies are able to account for a significant proportion of the heritability of common diseases, then genetic prediction has the potential to become much more powerful.
