included experiment-based RNA degradation metrics that account for batch effect and cell composition12,20. To increase detection power and improve effect size estimation, we applied the multivariate adaptive shrinkage (‘mash’21) method, which leverages the correlation structure of genetic ancestry effects across brain regions (Methods).Table 1BA sample characteristics for adult (age > 17) neurotypical control postmortem caudate nucleus, dentate gyrus, DLPFC and hippocampus (10–12)CharacteristicBrain regionCaudate nucleusDentate gyrusDLPFCHippocampusn = 122n = 47n = 123n = 133Sex, n (%) Female50 (41)16 (34)48 (39)53 (40) Male72 (59)31 (66)75 (61)80 (60)Age, mean (s.d.)46 (15)46 (16)44 (15)43 (15)RNA integrity number, mean (s.d.)7.83 (0.80)5.45 (1.22)7.70 (0.89)7.72 (0.98)
