These data are in line with results obtained in studies using dronabinol, another synthetic THC, in patients with chronic central neuropathic pain or fibromyalgia [5,213,214]. Dronabinol has been studied in healthy populations in a small double-blind randomized controlled trial (RCT) (n = 16; 7.5 mg) which showed reduced limbic reactivity to angry or fearful faces during an emotional faces processing task [178,215]. Dronabinol was also efficient in fear extinction, a key component of PTSD and anxiety disorders [216,217,218].
