in the foundation population also tended to drink more in the second half of the 4-hour DID test and that the allocation of consumption changed only mildly over selected generations. HDID-1 mice are clearly drinking more overall. A more fine-grained temporal analysis of intake such as the lickometer-derived data we reported for C57BL/6J mice (13) will be required to determine the role of pattern of intake on BEC. HDID-1 mice reached BEC levels greater than those seen in C57BL/6J mice tested under similar conditions (see Supplement 1).
