Laterality findings were also observed, with progressive left-lateralisation in older subjects or enhanced left frontal activation in adults relative to children [28, 43, 52]. However, as mentioned above, one study observed enhanced right superior frontal activation in children between 11 and 13 years relative to adults in a relatively small sample [49]. One of the first studies to investigate developmental changes in functional inter-regional connectivity networks during inhibition using independent component analyses, found that adolescents between 11 and 17 years relative to adults of 18–35 years had decreased connectivity in several inhibitory networks, including a medial network comprising anterior cingulate, inferior frontal lobe and parietal regions, as well as a more lateral IFC-striato-thalamic network, although some regions were strongly recruited in adolescents such as ventrolateral prefrontal lobe [33]. Furthermore, coupling between segregated inhibitory networks was reduced in adolescents [33], suggesting progressive functional integration within and between executive circuitries. During interference inhibition, using a psychophysiological interaction analysis, increased functional connectivity was observed within fronto-thalamic and fronto-parietal networks in adolescents between 14 and 15 years relative to children between 8 and 11
