Despite these efforts, the molecular, cellular, and neurobiological mechanisms of MD remain largely unidentified, limiting the development of disease models and mechanism-informed drug treatments.11 In this study, we report results from the Psychiatric Genomics Consortium (PGC) Major Depressive Disorder Working Group’s largest GWAS meta-analysis of MD to date (currently the largest GWAS study of any psychiatric disorder). We used strategies designed for the analysis of multi-ancestry and admixed populations to implement the largest, most inclusive study of MD genetics. These results substantially extend previous GWAS findings, implicating genes, cell types, and tissues in the etiology of MD, and demonstrate out-of-sample prediction across diverse ancestry groups.
